Abstract
Vasoactive intestinal peptide (VIP, EC50 = 6.4 X 10(-10)M) and histamine (EC50 = 3 X 10(-6)M) activated the cyclic AMP generating system in gastric glands isolated from two human fetuses at 23 weeks gestation. Histamine antagonism by the H2 receptor blockers cimetidine (Ki = 0.35 X 10(-6)M) and ranitidine (ki = 0.51 X 10(-7)M) clearly characterized the histaminic activation as being of the H2 type. It is suggested that these two vasoactive hormones may operate as neurocrine/paracrine regulators of the differentiation and/or function of the human gastric mucosa in utero.
MeSH terms
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Cimetidine / pharmacology
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Cyclic AMP / metabolism
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Female
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Fetus
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Gastric Mucosa / drug effects
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Gastric Mucosa / embryology
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Gastric Mucosa / metabolism*
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Histamine / pharmacology
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Humans
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Pregnancy
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Ranitidine / pharmacology
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Receptors, Cell Surface / metabolism*
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Receptors, Histamine / metabolism*
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Receptors, Histamine H2 / metabolism*
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Receptors, Vasoactive Intestinal Peptide
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Vasoactive Intestinal Peptide / metabolism*
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Vasoactive Intestinal Peptide / pharmacology
Substances
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Receptors, Cell Surface
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Receptors, Histamine
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Receptors, Histamine H2
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Receptors, Vasoactive Intestinal Peptide
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Vasoactive Intestinal Peptide
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Cimetidine
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Histamine
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Ranitidine
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Cyclic AMP