The development and validation of a LC-MS/MS method for the quantitation of metformin, rifampicin and isoniazid in rat plasma using HILIC chromatography

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Sep 15:1095:127-137. doi: 10.1016/j.jchromb.2018.07.041. Epub 2018 Jul 30.
No abstract available

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid / methods*
  • Drug Stability
  • Hydrophobic and Hydrophilic Interactions
  • Isoniazid / blood*
  • Isoniazid / chemistry
  • Isoniazid / pharmacokinetics
  • Limit of Detection
  • Linear Models
  • Male
  • Metformin / blood*
  • Metformin / chemistry
  • Metformin / pharmacokinetics
  • Rats
  • Rats, Sprague-Dawley
  • Reproducibility of Results
  • Rifampin / blood*
  • Rifampin / chemistry
  • Rifampin / pharmacokinetics
  • Tandem Mass Spectrometry / methods*

Substances

  • Metformin
  • Isoniazid
  • Rifampin