Many epidemiological studies revealed an association of dietary consumption of fatty acids and prostate cancer. Linoleic acid and alpha-linolenic acid and their derivatives such as arachidonic acid and eicosapentanoic acid are important polyunsaturated fatty acids in animal fats and in many vegetable oils. Their metabolism at the cellular level by enzymes such as lipoxygenases and cycloxygenases produces the group of eicosanoids molecules with many biological roles and activities in a variety of human diseases including cancer. In this review, we describe the biological activities of lipids with focus in eicosanoids and prostate cancer.
Keywords: 5-oxo-eicosatetraenoic acid (5-oxo-ETE); Arachidonic acid; Hydroxyeicosatetraenoic acids (HETEs); Lipoxygenases; Polyunsaturated fatty acids (PUFAs); Prostaglandins.