Demographic profile, clinicopathological spectrum, and treatment outcomes of primary central nervous system tumors: Retrospective audit from an academic neuro-oncology unit

Indian J Cancer. 2017 Oct-Dec;54(4):594-600. doi: 10.4103/ijc.IJC_543_17.

Abstract

Primary tumors of the central nervous system are relatively uncommon, comprising only 1%-2% of all neoplasms. However, they constitute the second most common type of malignancy in children (after leukemia) and the leading cause of cancer-related morbidity and mortality in children and young adults worldwide. Globally, there is substantial variability with nearly five-fold difference in incidence between various parts of the world. Brain tumors are quite heterogeneous with regard to histology, biological behavior, and prognosis mandating multidisciplinary therapeutic decision-making. This retrospective audit of all consecutive patients registered in a single calendar year (2013) in the neuro-oncology disease management group at Tata Memorial Centre is reflective of the ground reality and fair representation of outcomes in routine neuro-oncologic practice.

Keywords: Audit; brain tumors; epidemiology; neuro-oncology; outcomes.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Central Nervous System Neoplasms / classification
  • Central Nervous System Neoplasms / drug therapy*
  • Central Nervous System Neoplasms / epidemiology*
  • Central Nervous System Neoplasms / pathology
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Medical Oncology / trends
  • Middle Aged
  • Pathology, Molecular
  • Prognosis
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult