Concentration protocol of rhenium-188 perrhenate eluted from tungsten-188/rhenium-188 generator for the preparation of high-yield rhenium-188-labelled radiopharmaceuticals

Nucl Med Commun. 2018 Oct;39(10):957-959. doi: 10.1097/MNM.0000000000000893.

Abstract

Rhenium-188 (Re) is a β, γ emitter and considered a theranostic radionuclide. It is used for bone pain palliation, treatment of unresectable hepatocellular carcinoma, skin keloids, etc. Re perrhenate is eluted from a W/Re generator in large volumes (8-14 ml) of 0.9% normal saline. Concentrating Re to 1-2 ml volume is important for high radiolabelling yield of various Re radiopharmaceuticals, especially when the generator is old. For this, ion exchange column was prepared in-house, and Re was concentrated using silver ion exchange column and QMA cartridge. Re perrhenate eluted in saline was concentrated to 1 ml with more than 99% yield.

MeSH terms

  • Isotope Labeling
  • Radiochemistry
  • Radioisotopes / chemistry*
  • Radionuclide Generators*
  • Radiopharmaceuticals / chemistry*
  • Rhenium / chemistry*
  • Tungsten / chemistry*

Substances

  • Radioisotopes
  • Radiopharmaceuticals
  • Tungsten-188
  • perrhenate
  • Rhenium-188
  • Rhenium
  • Tungsten