Abstract
Herein, we designed and constructed a dual functional surface with antimicrobial and antifouling abilities to prevent protein and bacterial attachment that are significant challenges in biomedical devices. Primary amino-group-capped sulfobetaine of DMMSA was synthesized and then grafted onto polydopamine pretreated PET sheets via click chemistry. The sheets were subsequently immersed into silver ion solution, in which the absorbed silver ions were reduced to silver nanoparticles (AgNPs) in situ by a polydopamine layer. The antifouling assays demonstrated that the resultant PET/DMMSA/AgNPs sheets exhibited great antifouling performances against bovine serum albumin (BSA), bovine fibrinogen (BFG), platelets, and bacteria, the critical proteins/microorganisms leading to implant failure. The antibacterial data suggested that the sheets had dual functions as inhibitors of bacterial growth and bactericide and could efficiently delay the biofilm formation. This repelling and killing approach is green and simple, with potential biomedical applications.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adsorption / drug effects
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / toxicity
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Bacterial Adhesion / drug effects
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Betaine / analogs & derivatives
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Betaine / chemical synthesis
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Betaine / chemistry
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Betaine / toxicity
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Biofilms / drug effects
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Biofouling / prevention & control*
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Cattle
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Escherichia coli / physiology
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Fibrinogen / chemistry
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Hemolysis / drug effects
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Indoles / chemical synthesis
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Indoles / chemistry
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Indoles / toxicity
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / toxicity
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Mice
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Platelet Adhesiveness / drug effects
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Polyethylene Terephthalates / chemistry*
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Polyethylene Terephthalates / toxicity
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Polymers / chemical synthesis
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Polymers / chemistry
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Polymers / toxicity
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Rabbits
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Serum Albumin, Bovine / chemistry
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Silver / chemistry
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Silver / pharmacology*
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Silver / toxicity
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Indoles
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Polyethylene Terephthalates
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Polymers
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polydopamine
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Serum Albumin, Bovine
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Silver
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Betaine
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sulfobetaine
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Fibrinogen