HVEM LIGHTs the Way for ILC3s

Cell Host Microbe. 2018 Aug 8;24(2):187-188. doi: 10.1016/j.chom.2018.07.010.

Abstract

The early response to bacterial infection requires cytokine responses by immune cells. In this issue of Cell Host & Microbe, Seo et al. (2018) demonstrate that TNF-TNFR superfamily molecules LIGHT and HVEM stimulate early IFN-γ production by type 3 innate lymphoid cells, which are critical for defense against Yersinia enterocolitica.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Allogeneic Cells / immunology*
  • Animals
  • Humans
  • Immunity, Innate*
  • Interferon-gamma / immunology
  • Intestinal Diseases / immunology
  • Intestinal Diseases / microbiology
  • Lymphocytes / immunology*
  • Lymphotoxin-alpha / immunology*
  • Receptors, Tumor Necrosis Factor, Member 14 / immunology*
  • Yersinia Infections / immunology
  • Yersinia enterocolitica / immunology

Substances

  • Lymphotoxin-alpha
  • Receptors, Tumor Necrosis Factor, Member 14
  • Interferon-gamma