Effective inhibition of rifampicin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA polymerase inhibitor corallopyronin A

Int J Antimicrob Agents. 2018 Oct;52(4):523-524. doi: 10.1016/j.ijantimicag.2018.07.025. Epub 2018 Aug 6.
No abstract available

Publication types

  • Letter

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / pharmacology*
  • Chlamydia trachomatis / drug effects*
  • Chlamydia trachomatis / growth & development*
  • Chlamydia trachomatis / isolation & purification
  • DNA-Directed RNA Polymerases / antagonists & inhibitors*
  • Drug Resistance, Bacterial*
  • Epithelial Cells / microbiology
  • HeLa Cells
  • Humans
  • Lactones / administration & dosage
  • Lactones / pharmacokinetics
  • Lactones / pharmacology*
  • Mice
  • Microbial Sensitivity Tests
  • Plasma / chemistry
  • Rifampin / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Lactones
  • corallopyronin A
  • DNA-Directed RNA Polymerases
  • Rifampin