C-C bond cleavage in biosynthesis of 4-alkyl-L-proline precursors of lincomycin and anthramycin cannot precede C-methylation

Nat Commun. 2018 Aug 9;9(1):3167. doi: 10.1038/s41467-018-05455-3.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthramycin / chemistry*
  • Bacterial Proteins / chemistry
  • Carbon / chemistry*
  • Catalytic Domain
  • Lincomycin / chemistry*
  • Methylation
  • Molecular Structure
  • Mutation
  • Phenylpyruvic Acids / chemistry
  • Proline / chemistry*
  • Protein Binding
  • Streptomyces / chemistry*

Substances

  • Bacterial Proteins
  • Phenylpyruvic Acids
  • Anthramycin
  • Carbon
  • Proline
  • Lincomycin
  • phenylpyruvic acid