Abstract
The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects
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Fabaceae / chemistry*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Isoflavones / chemistry*
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Isoflavones / pharmacology*
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Millettia / chemistry*
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Stems / chemistry*
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Prenylation
Substances
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Anti-Bacterial Agents
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Isoflavones
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Plant Extracts