Secretory form of rheumatoid arthritis-associated autoantibodies in serum are mainly of the IgM isotype, suggesting a continuous reactivation of autoantibody responses at mucosal surfaces

Ann Rheum Dis. 2019 Jan;78(1):146-148. doi: 10.1136/annrheumdis-2018-213724. Epub 2018 Aug 14.

Authors

Myrthe A M van Delft¹, Diane van der Woude¹, René E M Toes¹, Leendert A Trouw²

Affiliations

¹ Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 30108046
DOI: 10.1136/annrheumdis-2018-213724

No abstract available

Keywords: ant-ccp; autoantibodies; autoimmunity; rheumatoid arthritis; rheumatoid factor.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid / immunology*
Autoantibodies / immunology*
Humans
Immunity, Active
Immunity, Mucosal / immunology*
Immunoglobulin Isotypes / immunology*
Immunoglobulin M / immunology*

Substances

Autoantibodies
Immunoglobulin Isotypes
Immunoglobulin M