Mutant NRAS Q61K is responsible for MAPK pathway activation in the MARIMO cell line and renders these cells independent of the CALR-MPL-JAK2-STAT5 pathway

Leukemia. 2018 Sep;32(9):2087-2090. doi: 10.1038/s41375-018-0234-6. Epub 2018 Aug 8.

Authors

Lijuan Han¹, Julia Czech¹, Angela Maurer¹, Tim H Brümmendorf¹, Nicolas Chatain¹, Steffen Koschmieder²

Affiliations

¹ Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
² Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany. [email protected].

PMID: 30115971
DOI: 10.1038/s41375-018-0234-6

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Amino Acid Substitution
Calreticulin / metabolism*
Cell Line, Tumor
GTP Phosphohydrolases / genetics*
High-Throughput Nucleotide Sequencing
Humans
Janus Kinase 2 / metabolism*
Leukemia, Erythroblastic, Acute / genetics*
Leukemia, Erythroblastic, Acute / metabolism*
Leukemia, Erythroblastic, Acute / pathology
Membrane Proteins / genetics*
Mutation*
Receptors, Thrombopoietin / metabolism*
STAT5 Transcription Factor / metabolism*
Signal Transduction*

Substances

CALR protein, human
Calreticulin
Membrane Proteins
Receptors, Thrombopoietin
STAT5 Transcription Factor
MPL protein, human
JAK2 protein, human
Janus Kinase 2
GTP Phosphohydrolases
NRAS protein, human