TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice

Blood Adv. 2018 Aug 28;2(16):2072-2078. doi: 10.1182/bloodadvances.2018017756.

Abstract

  1. Platelet activation in vitro results in a more rapid and greater upregulation of TLT-1 surface expression compared with P-selectin.

  2. TLT-1 is more rapidly translocated to the surface of activated platelets than P-selectin during thrombus formation in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Blood Platelets / cytology
  • Blood Platelets / metabolism*
  • Humans
  • Mice
  • P-Selectin / metabolism
  • Platelet Activation*
  • Receptors, Immunologic / metabolism*

Substances

  • Biomarkers
  • P-Selectin
  • Receptors, Immunologic
  • TREML1 protein, human
  • Treml1 protein, mouse