Hepatocellular carcinoma (HCC) in Indonesia ranks as the 9th most common of cancers. The ratio of male and female in HCC 2.5:1. HCC were found mostly in the 4th to 7th decade of life. HCC is frequently accompanied with cirrhosis and close relationship with HBV. The positivity of HBV marker is 60% in CLD and 67% in HCC. The patients usually come late to the doctors, and early detection is still a problem. Ultrasonography every 4 months and serologic test every month in CLD is recommended. Ultrasonically guided fine needle aspiration biopsy is quite promising for diagnosis and early detection of HCC.