Gene and Cell Therapy for Muscular Dystrophies: Are We Getting There?

Hum Gene Ther. 2018 Oct;29(10):1098-1105. doi: 10.1089/hum.2018.151.

Abstract

In the last few years, significant advances have occurred in the preclinical and clinical work toward gene and cell therapy for muscular dystrophy. At the time of this writing, several trials are ongoing and more are expected to start. It is thus a time of expectation, even though many hurdles remain and it is unclear whether they will be overcome with current strategies or if further improvements will be necessary.

Keywords: cell therapy; gene therapy; muscular dystrophy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell- and Tissue-Based Therapy* / methods
  • Gene Expression
  • Gene Expression Regulation
  • Gene Transfer Techniques
  • Genetic Therapy* / methods
  • Genetic Vectors / genetics
  • Humans
  • Muscular Dystrophies / genetics*
  • Muscular Dystrophies / therapy*
  • Organ Specificity / genetics
  • Transduction, Genetic
  • Transgenes