Objective: To optimize the material composition of Huang-ma slow-release membrane spray agent and to examine its delivery evaluation and transdermal release law in vitro.
Methods: The dosage of PVA17-88,ethanol and glycerin were used as factors, the film-forming properties,the release rate of strychnine and berberine hydrochloride in eight hours were adopted as indexes to optimize the molding process; the release rate and transdermal release were examined in vitro by using Franz diffusion cells.
Results: The optimum extraction technology in vitro was 5% of PVA17-88,15% of ethanol, and 6% of glycerin; Huang-ma slow-release membrane spray agent had the characteristics of good release and kinetic equation with good film-forming properties in eight hours.
Conclusion: The formula and the preparation methods are both feasible, the drug can be sprayed evenly, quantitatively slow released; it has a protective effect on wound with little irritation after filming,and has good adhesion and flexibility as well.