Human cGAS Has a Slightly Different Taste for dsDNA

Alexiane Decout; Andrea Ablasser

doi:10.1016/j.immuni.2018.08.005

Human cGAS Has a Slightly Different Taste for dsDNA

Immunity. 2018 Aug 21;49(2):206-208. doi: 10.1016/j.immuni.2018.08.005.

Authors

Alexiane Decout¹, Andrea Ablasser²

Affiliations

¹ Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
² Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address: [email protected].

PMID: 30134199
DOI: 10.1016/j.immuni.2018.08.005

Abstract

The nucleotidyltransferase cGAS performs a crucial role in innate immunity by binding double-stranded DNA and catalyzing the production of cGAMP. A structure of the human cGAS-DNA complex reported in Cell provides a fresh perspective on its mechanism of activation.

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MeSH terms

DNA
Humans
Immunity, Innate
Immunologic Surveillance
Nucleotidyltransferases*
Taste*

Substances

DNA
Nucleotidyltransferases