Abstract
The dissociative anaesthetics, phencyclidine and ketamine, block excitation of central neurones by N-methylaspartate. Using the technique of microelectrophoresis on rat spinal neurones in vivo Metaphit, a phencyclidine receptor acylating agent, was tested to see whether it would antagonise this effect of dissociative anaesthetics. The predominant effect of Metaphit was, however, to reduce N-methylaspartate induced excitation. It is concluded that Metaphit has mixed agonist/antagonist effects at the phencyclidine receptor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects*
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Animals
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / antagonists & inhibitors
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Depression, Chemical
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Drug Interactions
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Kainic Acid / pharmacology
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Ketamine / pharmacology*
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N-Methylaspartate
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Neurons / drug effects
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Oxadiazoles / pharmacology
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Phencyclidine / analogs & derivatives*
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Phencyclidine / antagonists & inhibitors*
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Phencyclidine / pharmacology
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Quisqualic Acid
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Rats
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Receptors, Opioid / drug effects
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Receptors, sigma
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Spinal Cord / drug effects*
Substances
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Oxadiazoles
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Receptors, Opioid
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Receptors, sigma
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Aspartic Acid
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N-Methylaspartate
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Ketamine
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Quisqualic Acid
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metaphit
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Phencyclidine
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Kainic Acid