Medical Rehabilitation: Guidelines to Advance the Field With High-Impact Clinical Trials

Marcas M Bamman; Gary R Cutter; David M Brienza; John Chae; Daniel M Corcos; Stephanie DeLuca; Edelle Field-Fote; Mona N Fouad; Catherine E Lang; Anne Lindblad; Robert W Motl; Carla G Perna; Darcy Reisman; Kenneth M Saag; Sean I Savitz; Kathryn H Schmitz; Jennifer Stevens-Lapsley; John Whyte; Carolee J Winstein; Mary E Michel

doi:10.1016/j.apmr.2018.08.173

Medical Rehabilitation: Guidelines to Advance the Field With High-Impact Clinical Trials

Arch Phys Med Rehabil. 2018 Dec;99(12):2637-2648. doi: 10.1016/j.apmr.2018.08.173. Epub 2018 Aug 24.

Authors

Marcas M Bamman¹, Gary R Cutter², David M Brienza³, John Chae⁴, Daniel M Corcos⁵, Stephanie DeLuca⁶, Edelle Field-Fote⁷, Mona N Fouad⁸, Catherine E Lang⁹, Anne Lindblad¹⁰, Robert W Motl¹¹, Carla G Perna¹², Darcy Reisman¹³, Kenneth M Saag¹⁴, Sean I Savitz¹⁵, Kathryn H Schmitz¹⁶, Jennifer Stevens-Lapsley¹⁷, John Whyte¹⁸, Carolee J Winstein¹⁹, Mary E Michel²⁰

Affiliations

¹ NIH National Rehabilitation Research Resource to Enhance Clinical Trials (REACT, P2CHD086851), Birmingham, AL; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL. Electronic address: [email protected].
² NIH National Rehabilitation Research Resource to Enhance Clinical Trials (REACT, P2CHD086851), Birmingham, AL; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL; Section on Research Methods and Clinical Trials, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL.
³ Department of Rehabilitation Science and Technology and McGowan Institute for Regenerative Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.
⁴ Department of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland, OH.
⁵ Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL.
⁶ Virginia Tech Carilion Research Institute, Roanoke, VA.
⁷ Virginia C. Crawford Research Institute, Shepherd Center, Atlanta, GA and Division of Physical Therapy, Emory University School of Medicine, Atlanta, GA.
⁸ NIH National Rehabilitation Research Resource to Enhance Clinical Trials (REACT, P2CHD086851), Birmingham, AL; Division of Preventive Medicine, Department of Medicine and Minority Health and Health Disparities Research Center, University of Alabama at Birmingham, Birmingham, AL.
⁹ Physical Therapy, Occupational Therapy, and Neurology, Washington University School of Medicine, St. Louis, MO.
¹⁰ The Emmes Corporation, Rockville, MD.
¹¹ NIH National Rehabilitation Research Resource to Enhance Clinical Trials (REACT, P2CHD086851), Birmingham, AL; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL; Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL.
¹² NIH National Rehabilitation Research Resource to Enhance Clinical Trials (REACT, P2CHD086851), Birmingham, AL; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL.
¹³ Department of Physical Therapy, University of Delaware, Newark, DE.
¹⁴ NIH National Rehabilitation Research Resource to Enhance Clinical Trials (REACT, P2CHD086851), Birmingham, AL; Division of Clinical Immunology and Rheumatology, Department of Medicine and Center for Outcomes and Effectiveness Research and Education, University of Alabama at Birmingham, Birmingham, AL.
¹⁵ Department of Neurology, University of Texas Health Science Center, Houston, TX.
¹⁶ Department of Public Health Sciences, Pennsylvania State University, State College, PA.
¹⁷ Physical Therapy Program, University of Colorado, Denver, CO.
¹⁸ Moss Rehabilitation Research Institute, Einstein Medical Center, Philadelphia, PA.
¹⁹ Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA.
²⁰ National Center for Medical Rehabilitation Research, National Institutes of Health, Bethesda, MD.

PMID: 30148997
DOI: 10.1016/j.apmr.2018.08.173

Abstract

The purpose of this Special Communication is to summarize guidelines and recommendations stemming from an expert panel convened by the National Institutes of Health, National Center for Medical Rehabilitation Research (NCMRR) for a workshop entitled The Future of Medical Rehabilitation Clinical Trials, held September 29-30, 2016, at the NCMRR offices in Bethesda, Maryland. The ultimate goal of both the workshop and this summary is to offer guidance on clinical trials design and operations to the medical rehabilitation research community, with the intent of maximizing the effect of future trials.

Keywords: Clinical trial; Guideline; Rehabilitation.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Clinical Trials as Topic / methods*
Congresses as Topic
Forecasting
Guidelines as Topic*
Humans
National Institutes of Health (U.S.)
Physical and Rehabilitation Medicine / trends*
Rehabilitation Research / standards*
Research Design
United States

Grants and funding

P2C HD086851/HD/NICHD NIH HHS/United States