Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration

Hu Wang; Hongna Zuo; Jin Liu; Fei Wen; Yawei Gao; Xudong Zhu; Bo Liu; Feng Xiao; Wengong Wang; Gang Huang; Bin Shen; Zhenyu Ju

doi:10.1038/s41422-018-0082-y

Loss of YTHDF2-mediated m⁶A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration

Cell Res. 2018 Oct;28(10):1035-1038. doi: 10.1038/s41422-018-0082-y. Epub 2018 Aug 27.

Authors

Hu Wang^#^{1

2}, Hongna Zuo^#³, Jin Liu⁴, Fei Wen³, Yawei Gao⁵, Xudong Zhu³, Bo Liu⁴, Feng Xiao⁴, Wengong Wang⁶, Gang Huang⁷, Bin Shen⁸, Zhenyu Ju^{9

10}

Affiliations

¹ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China. [email protected].
² Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang, 311121, China. [email protected].
³ Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang, 311121, China.
⁴ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.
⁵ Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
⁶ Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China.
⁷ Division of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Room S7.224, Cincinnati, OH, USA.
⁸ Department of Histology and Embryology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. [email protected].
⁹ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China. [email protected].
¹⁰ Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang, 311121, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Marrow Cells / cytology
Cell Proliferation / drug effects
Cell Proliferation / radiation effects
Cell Self Renewal / drug effects
Cell Self Renewal / radiation effects
Cells, Cultured
Fluorouracil / pharmacology
Hematopoietic Stem Cells / cytology
Hematopoietic Stem Cells / metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
RNA, Messenger / metabolism*
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism*
Radiation, Ionizing
Transcriptome / drug effects
Transcriptome / radiation effects

Substances

RNA, Messenger
RNA-Binding Proteins
YTHDF2 protein, mouse
Fluorouracil