A novel HLA-B variant, HLA-B*14:02:16, discovered by amplicon-based next-generation sequencing

HLA. 2018 Nov;92(5):323-324. doi: 10.1111/tan.13384. Epub 2018 Oct 25.

Authors

Vera Balz¹, Johannes Fischer¹, Stefan Krause¹, Juergen Enczmann¹

Affiliation

¹ Institute for Transplantation Diagnostics and Cell Therapeutics, University Hospital of Duesseldorf, Duesseldorf, Germany.

PMID: 30156043
DOI: 10.1111/tan.13384

Abstract

HLA-B*14:02:16 differs from B*14:02:01:01 by a synonymous nucleotide substitution in codon 141.

Keywords: next-generation sequencing; novel HLA-B allele; synonymous variation.

© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Blood Donors*
Codon*
Genetic Variation*
Genotype
HLA-B14 Antigen / genetics*
Hematopoietic Stem Cell Transplantation*
High-Throughput Nucleotide Sequencing / methods*
Histocompatibility Testing / methods*
Humans
Male
Polymerase Chain Reaction
Sequence Analysis, DNA / methods
Sequence Homology
Silent Mutation

Substances

Codon
HLA-B*14:02 antigen
HLA-B14 Antigen