X-linked dominant hypophosphatemia is closely linked to DNA markers DXS41 and DXS43 at Xp22

Hum Genet. 1986 Jul;73(3):271-5. doi: 10.1007/BF00401243.

Abstract

Two families with X-linked dominant hypophosphatemia (McKusick No. *30780) were investigated for linkage of the disease locus with several marker genes defined by cloned, single-copy DNA sequences derived from defined regions of the X chromosome. Close linkage was found with DNA markers DXS41 (p99-6) and DXS43 (pD2) at Xp22, suggesting a location of the HPDR gene on the distal short arm of the X chromosome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • DNA / genetics
  • Female
  • Genes, Dominant*
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Hypophosphatemia, Familial / genetics*
  • Male
  • Pedigree
  • Phosphates / blood*
  • X Chromosome*

Substances

  • Genetic Markers
  • Phosphates
  • DNA