Transcatheter aortic valve implantation (TAVI) has become the preferred method of treatment for high-risk patients with severe symptomatic aortic stenosis (AS) and is a preferred alternative to surgical valve replacement for intermediate-risk patients. Stroke remains one of the most clinically devastating complications following TAVI. We review the incidence of neurologic injury related to TAVI, proposed definitions for neurologic events and current evidence for neuroprotection and adjunctive pharmacotherapy.