Tank Circuit for Ultrafast Single-Particle Detection in Micropores

Phys Rev Lett. 2018 Aug 17;121(7):078102. doi: 10.1103/PhysRevLett.121.078102.

Abstract

We present an ultrafast single submicron particle detection method based on a half-bowtie coplanar waveguide. The method is capable of resolving the translocation of these particles at a bandwidth greater than 30 MHz. We compare experimentally the simultaneous use of our radio-frequency technique with conventional dc based resistive pulse recordings and find that our method has a throughput that is enhanced by 2 orders of magnitude. The technique incorporates a microfluidic circuit and has the potential to be employed for screening microparticles and biological cells at frequencies in excess of 1 GHz.

MeSH terms

  • Biophysics / instrumentation
  • Biophysics / methods
  • DNA / analysis
  • Lab-On-A-Chip Devices*
  • Microfluidic Analytical Techniques / instrumentation
  • Microfluidic Analytical Techniques / methods
  • Particle Size

Substances

  • DNA