The mechanical and hemodynamic effects of left ventricular pacing in heart failure with preserved ejection fraction and left bundle branch block

J Electrocardiol. 2018 Sep-Oct;51(5):859-862. doi: 10.1016/j.jelectrocard.2018.07.004. Epub 2018 Jul 10.

Abstract

Cardiac resynchronization therapy (CRT) has revolutionized the care of patients with heart failure with reduced ejection fraction (HFrEF) and left bundle branch block (LBBB); some hypothesize that electrical resynchronization may also benefit patients with heart failure with preserved ejection fraction (HFpEF) and LBBB. We assessed the acute hemodynamic and mechanical impact of temporary LV pacing in 2 patients with HFpEF and LBBB and a "classic" pattern of echocardiographic dyssynchrony. LV pacing facilitated electrical resynchronization with acute resolution of mechanical dyssynchrony and improvements in invasively and non-invasively measured global cardiac function, due in part to shortening of the isovolumetric contraction period.

Keywords: Cardiac resynchronization therapy; Heart failure with preserved ejection fraction; Left bundle branch block.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bundle-Branch Block / complications
  • Bundle-Branch Block / physiopathology
  • Bundle-Branch Block / therapy*
  • Cardiac Resynchronization Therapy*
  • Echocardiography
  • Electrocardiography
  • Female
  • Heart / diagnostic imaging
  • Heart / physiopathology*
  • Heart Failure / complications
  • Heart Failure / physiopathology
  • Heart Failure / therapy*
  • Hemodynamics
  • Humans
  • Male
  • Stroke Volume