Abstract
Some 3-amino- and 3-hydroxy-8-halosubstituted 6H-indolo[2,3-b] [1,8]naphthyridines were synthesized and tested for their affinity for the benzodiazepine receptor in bovine cortical membranes. All prepared compounds were more active than the corresponding 8-unsubstituted derivatives. Moreover, among these compounds the 8-chloroindolonaphthyridines were clearly the most potent.
MeSH terms
-
Animals
-
Binding, Competitive / drug effects
-
Brain / metabolism
-
Cattle
-
Chemical Phenomena
-
Chemistry
-
Flunitrazepam / metabolism
-
In Vitro Techniques
-
Indoles / chemical synthesis*
-
Indoles / pharmacology
-
Naphthyridines / chemical synthesis*
-
Naphthyridines / pharmacology
-
Receptors, GABA-A / drug effects*
Substances
-
Indoles
-
Naphthyridines
-
Receptors, GABA-A
-
Flunitrazepam