This paper introduces the Risk of Bias in Systematic Review (ROBIS), including: 1) the development of ROBIS, 2) three phases of ROBIS tool judging the overall risk of bias that related to systematic reviews, and 3) illustration on the application of ROBIS in a published systematic review. ROBIS is the first rigorously developed tool which is specifically designed to assess the risk of bias in systematic reviews. ROBIS will help improve the process of risk assessment on bias which appeared in overviews and guidelines.
针对评价系统综述偏倚风险的ROBIS（Risk of Bias in Systematic Review）工具进行详细介绍，包括ROBIS的制定过程、应用ROBIS对系统综述进行评价的3个阶段、并举例说明ROBIS的使用方法和注意事项。ROBIS与AMSTAR（A Measurement Tool to Assess Systematic Reviews）工具不同，是第一个制定出用于全面评价系统综述偏倚风险的工具，为研究者制定临床实践指南或系统综述再评价提供依据。.
Keywords: Randomized controlled trial; Risk of bias; Systematic review; Tool for assessment.