Abstract
Two new triterpenoids, vistriterpenoids A (1) and B (2), and four known ones, were acquired from Dodonaea viscosa. Compounds 1 and 2 represent the 24-nor-oleanane triterpenoids isolated from the genus Dodonaea for the first time. Their structures were identified based on extensive spectroscopic methods. Compounds 1, 2, 5, and 6 exerted inhibitory activities against PTP1B in vitro.
Keywords:
Dodonaea viscosa; PTP1B inhibitors; inhibitory activity; protein tyrosine phosphatase 1b (PTP1B); triterpenoids; vistriterpenoids A and B.
© 2018 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Humans
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Molecular Conformation
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism
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Sapindaceae / chemistry*
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Structure-Activity Relationship
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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Enzyme Inhibitors
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Triterpenes
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PTPN1 protein, human
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Protein Tyrosine Phosphatase, Non-Receptor Type 1