IFN-γ Promotes, but Dexamethasone Dissociates, Toll-Like Receptor 2/1-Induced Host Responses in Human Macrophages

J Invest Dermatol. 2019 Feb;139(2):488-491. doi: 10.1016/j.jid.2018.07.035. Epub 2018 Sep 5.

Authors

Philipp Kröll¹, Kristin Knoke¹, Julia Steiger¹, Mario Fabri²

Affiliations

¹ Department of Dermatology, University of Cologne, Cologne, Germany.
² Department of Dermatology, University of Cologne, Cologne, Germany. Electronic address: [email protected].

PMID: 30193757
DOI: 10.1016/j.jid.2018.07.035

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Blood Buffy Coat / cytology
Cells, Cultured
Dexamethasone / administration & dosage*
Healthy Volunteers
Host Microbial Interactions / immunology*
Humans
Immunity, Innate / drug effects*
Interferon-gamma / administration & dosage*
Macrophages / drug effects
Macrophages / immunology*
Macrophages / microbiology
Mycobacterium bovis / immunology
Primary Cell Culture
Signal Transduction / drug effects
Signal Transduction / immunology
Toll-Like Receptor 1 / immunology
Toll-Like Receptor 1 / metabolism
Toll-Like Receptor 2 / immunology
Toll-Like Receptor 2 / metabolism

Substances

TLR1 protein, human
TLR2 protein, human
Toll-Like Receptor 1
Toll-Like Receptor 2
Dexamethasone
Interferon-gamma