Interest of immunodeficiency screening in adult after admission in medical intensive care unit for severe infection, a retrospective and a prospective study: the Intensive Care Unit and Primary and Secondary Immunodeficiency (ICUSPID) study

Infection. 2019 Feb;47(1):87-93. doi: 10.1007/s15010-018-1215-4. Epub 2018 Sep 7.

Aurélie Baldolli^{1

2}, Nicolas Martin Silva³, Amélie Seguin⁴, Gwenola Maigne³, Audrey Sultan³, Samuel Deshayes³, Damien Du Cheyron⁴, Aurélie Joret⁴, Nizar Mahlaoui^{5

6

7}, Boris Bienvenu⁸

¹ Department of Infectious Diseases, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France. [email protected].
² Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université Caen Normandie, 14000, Caen, France. [email protected].
³ Department of Internal Medicine, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France.
⁴ Department of Intensive Care Unit, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France.
⁵ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁶ Pediatric Immuno-Haematology and Rheumatology Unit, Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁷ INSERM UMR1163, Imagine Institute, Sorbonne Paris Cité, University Paris Descartes, Paris, France.
⁸ Internal Medicine Department, Saint-Joseph Hospital, Boulevard de Louvain, 13008, Marseille, France.

Abstract

Background: Primary immunodeficiency (PID) in adults is rare and mostly revealed by infections.

Material and methods: Adults without predisposing factors who were admitted to an intensive care unit (ICU) for infection were screened for PID.

Results: Six PID cases were diagnosed, mostly revealed by encapsulated bacterial infections.

Conclusion: Investigation of PID after ICU discharge should be considered to improve early detection.

Keywords: Adult; Infection; Intensive care unit; Primary immunodeficiency; Secondary immunodeficiency.