Abstract
Soluble membrane fractions derived from polyoma tumor cells trigger lymphocytes, derived from polyoma-immunized animals, but not from nonimmunized controls, to release the lymphokine, macrophage migration-inhibitory factor. The reaction can be blocked by sera from polyoma-bearing animals. Absorption of these sera with polyoma cells, but not with nonpolyoma cell lines, abrogates this activity. These findings suggest that there is a polyoma virus-induced membrane component that can induce polyoma-specific macrophage migration inhibition.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology
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Antigens, Polyomavirus Transforming
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Antigens, Surface / analysis*
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Antigens, Viral, Tumor / analysis*
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Cell Migration Inhibition*
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Macrophages / immunology*
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Mice
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Oncogene Proteins, Viral / analysis
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Polyomavirus / immunology*
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Rats
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Tumor Virus Infections / immunology
Substances
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Antibodies, Monoclonal
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Antigens, Polyomavirus Transforming
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Antigens, Surface
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Antigens, Viral, Tumor
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Oncogene Proteins, Viral