Abstract
The active metabolites investigation of Talaromyces sp. (strain No. MH551540) associated with Xanthoparmelia angustiphylla afforded one new δ-lactone, talaromycin A (1), together with six known compounds, clearanol A (2), 6-methylbiphenyl-3,3',4,5'-tetraol (3), desmethylaltenusin (4), ergone (5), ergosterol (6), and palmitic acid (7). The structures of these compounds were elucidated by a combination of spectroscopic-data interpretation and single-crystal X-ray diffraction analysis. The cytotoxicities of 1-7 and the antioxidant activities of 3 and 4 were also evaluated.
Keywords:
Talaromyces; antioxidant activity; biological activity; cytotoxicity; endolichenic fungus; metabolites; talaromycin A.
© 2018 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / metabolism
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antioxidants / chemistry
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Antioxidants / metabolism
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Antioxidants / pharmacology*
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Biphenyl Compounds / antagonists & inhibitors
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Cell Line, Tumor
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Free Radicals / antagonists & inhibitors
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Humans
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Lactones / metabolism*
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Lactones / pharmacology
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Molecular Structure
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Parmeliaceae / chemistry
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Parmeliaceae / metabolism
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Picrates / antagonists & inhibitors
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Structure-Activity Relationship
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Talaromyces / chemistry*
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Talaromyces / metabolism
Substances
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Biphenyl Compounds
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Free Radicals
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Lactones
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Picrates
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1,1-diphenyl-2-picrylhydrazyl