[JUN N-TERMINAL KINASES AND THEIR PHARMACOLOGICAL MODULATION OF ISCHE-MIC AND REPERFUSION INJURY OF THE BRAIN]

Ross Fiziol Zh Im I M Sechenova. 2017 Mar;103(3):268-83.
[Article in Russian]

Abstract

The article reviews the literature regarding the role of c-Jun-N-terminal kinases (JNK) and its inhibitors in brain damage in the settings of ischemia and reperfusion injury. The implication of JNK in signaling mechanisms involved in ischemia-reperfusion-induced cerebral injury are discussed. Described effects associated with JNK inhibition using synthetic and natural substances in experimental models of ischemic and reperfusion injury of the brain. Results of experimental studies demonstrated that JNK represent promising therapeutic targets for brain protection against ischemic stroke. However, multiple physiologic functions of various JNK family members do not allow for the systemic use of non-specific JNK inhibitors for therapeutic purposes. The authors conclude that the continuous search for selective inhibitors of JNK3 remains an important task.

Publication types

  • Review

MeSH terms

  • Acetonitriles / pharmacology
  • Animals
  • Anthracenes / pharmacology
  • Benzothiazoles / pharmacology
  • Brain / drug effects
  • Brain / enzymology
  • Brain / pathology
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / enzymology
  • Brain Ischemia / genetics
  • Brain Ischemia / pathology
  • Gene Expression Regulation
  • Ginsenosides / isolation & purification
  • Ginsenosides / pharmacology
  • Humans
  • JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors*
  • JNK Mitogen-Activated Protein Kinases / genetics
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Mitogen-Activated Protein Kinase 10 / antagonists & inhibitors
  • Mitogen-Activated Protein Kinase 10 / genetics
  • Mitogen-Activated Protein Kinase 10 / metabolism
  • Neuroprotective Agents / pharmacology*
  • Oximes / pharmacology
  • Plant Extracts / chemistry
  • Protein Kinase Inhibitors / pharmacology*
  • Quinoxalines / pharmacology
  • Reperfusion Injury / drug therapy*
  • Reperfusion Injury / enzymology
  • Reperfusion Injury / genetics
  • Reperfusion Injury / pathology
  • Signal Transduction

Substances

  • 1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile
  • 11H-indeno(1,2-b)quinoxalin-11-one oxime
  • Acetonitriles
  • Anthracenes
  • Benzothiazoles
  • Ginsenosides
  • Neuroprotective Agents
  • Oximes
  • Plant Extracts
  • Protein Kinase Inhibitors
  • Quinoxalines
  • pyrazolanthrone
  • Mitogen-Activated Protein Kinase 10
  • JNK Mitogen-Activated Protein Kinases