Lack of correlation of ECV and outcome in an in vivo murine model of systemic fusariosis

Diagn Microbiol Infect Dis. 2018 Oct;92(2):124-126. doi: 10.1016/j.diagmicrobio.2018.05.019. Epub 2018 May 29.

Abstract

The efficacy of liposomal amphotericin B and voriconazole was evaluated against the systemic infection by Fusarium oxysporum species complex or Fusarium keratoplasticum. Although MIC values were within the epidemiological cutoff values (ECVs) recently stablished for Fusarium spp., no efficacy was obtained, indicating that ECVs for Fusarium are not relevant for in vivo efficacy.

Keywords: Animal model; Antifungal therapy; Fusariosis; Fusarium; Liposomal amphotericin B; Voriconazole.

MeSH terms

  • Amphotericin B / pharmacology*
  • Animals
  • Antifungal Agents / pharmacology*
  • Disease Models, Animal
  • Fusariosis / drug therapy*
  • Fusarium / drug effects*
  • Mice
  • Voriconazole / pharmacology*

Substances

  • Antifungal Agents
  • liposomal amphotericin B
  • Amphotericin B
  • Voriconazole