Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs

Chin Med J (Engl). 2018 Sep 20;131(18):2229-2231. doi: 10.4103/0366-6999.240800.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADAMTS4 Protein / genetics
  • ADAMTS4 Protein / metabolism
  • ADAMTS5 Protein / genetics
  • ADAMTS5 Protein / metabolism*
  • Aged
  • Aggrecans / genetics
  • Aggrecans / metabolism*
  • Cells, Cultured
  • Chondrocytes / drug effects
  • Chondrocytes / metabolism
  • Collagen Type II / metabolism
  • Extracellular Matrix / drug effects*
  • Extracellular Matrix / metabolism*
  • Humans
  • Middle Aged
  • Osteoarthritis / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Stress, Mechanical*
  • Verapamil / pharmacology*

Substances

  • Aggrecans
  • Collagen Type II
  • RNA, Messenger
  • Verapamil
  • ADAMTS5 Protein
  • ADAMTS4 Protein