Outbreak of Hypervirulent Multidrug-resistant Klebsiella variicola Causing High Mortality in Neonates in Bangladesh

Clin Infect Dis. 2019 Mar 19;68(7):1225-1227. doi: 10.1093/cid/ciy778.

Abstract

We report a clonal outbreak of multidrug-resistant (MDR) Klebsiella variicola (sequence type [ST] 771) in a Bangladeshi neonatal unit from October 2016 to January 2017, associated with high mortality (54.5%). During the outbreak, K. variicola ST771 acquired an MDR plasmid harboring blaNDM-1, linked to high exposure to ceftriaxone and amikacin.

Keywords: Klebsiella variicola; Bangladesh; NICU; outbreak.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amikacin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Bangladesh / epidemiology
  • Ceftriaxone / therapeutic use
  • Disease Outbreaks*
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Genotype
  • Humans
  • Infant, Newborn
  • Klebsiella / classification
  • Klebsiella / drug effects
  • Klebsiella / genetics
  • Klebsiella / isolation & purification*
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / microbiology
  • Klebsiella Infections / mortality*
  • Male
  • Plasmids / analysis
  • Survival Analysis
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone
  • Amikacin
  • beta-Lactamases
  • beta-lactamase NDM-1

Supplementary concepts

  • Klebsiella variicola