Long-Term Engraftment (16 Years) of Myoblasts in a Human Infarcted Heart

Stem Cells Transl Med. 2018 Oct;7(10):705-708. doi: 10.1002/sctm.18-0017. Epub 2018 Sep 13.

Abstract

We report the case of a patient who had undergone injections of myoblasts in an infarct area 16 years before being referred for heart transplantation. The pathological examination of the explanted heart found persisting myotubes embedded in fibrosis. This finding supports the ability of myoblasts to survive in harsh environments, which can make them appealing candidates for transplantation in diseases requiring supply of new myogenic cells. Stem Cells Translational Medicine 2018;7:705-708.

Keywords: Clinical cell transplantation; Heart failure; Long-term follow-up; Myoblasts.

MeSH terms

  • Adult
  • Fibrosis
  • Humans
  • Male
  • Muscle Fibers, Skeletal / metabolism
  • Muscle Fibers, Skeletal / pathology
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / pathology
  • Myoblasts, Skeletal / cytology
  • Myoblasts, Skeletal / metabolism
  • Myoblasts, Skeletal / transplantation*
  • Myocardial Infarction / pathology
  • Myocardial Infarction / therapy*
  • Myocardium / pathology
  • Myosin Heavy Chains
  • Troponin T / metabolism
  • Ventricular Function, Left / physiology

Substances

  • Troponin T
  • Myosin Heavy Chains