The first case of deafness-dystonia syndrome due to compound heterozygous variants in FITM2

Clin Case Rep. 2018 Jul 26;6(9):1815-1817. doi: 10.1002/ccr3.1719. eCollection 2018 Sep.

Abstract

We report the second known family affected by deafness-dystonia syndrome associated with loss of function of FITM2. Our patient is compound heterozygous for pathogenic FITM2 variants, while affected siblings in the first report were homozygous. This case provides evidence that this novel genetic disorder is associated with autosomal recessive inheritance.

Keywords: FITM2; Siddiqi syndrome; deafness‐dystonia syndrome.

Publication types

  • Case Reports