Abstract
The binding of HDL, Apo-E-free, was studied in rats fed a cholesterol rich diet for 2, 4 and 7 days. Plasma cholesterol increased up to 16-fold (from 55 to 900 mg/dl); liver cholesterol was also raised, from 0.5 to 16 mg/g of tissue. The HDL binding to membrane preparations was not affected while the binding of beta VLDL was reduced to about 50% of the controls. These data show, therefore, that liver binding sites for HDL are refractory to regulation by dietary cholesterol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carrier Proteins*
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Cell Membrane / metabolism
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Cholesterol / blood
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Cholesterol / metabolism
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Cholesterol, Dietary / pharmacology*
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Lipoproteins, HDL / metabolism*
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Lipoproteins, VLDL / metabolism
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Liver / drug effects
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Liver / metabolism*
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Male
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RNA-Binding Proteins*
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Rats
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Receptors, Cell Surface / drug effects
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Receptors, Cell Surface / metabolism
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Receptors, Lipoprotein*
Substances
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Carrier Proteins
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Cholesterol, Dietary
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Lipoproteins, HDL
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Lipoproteins, VLDL
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RNA-Binding Proteins
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Receptors, Cell Surface
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Receptors, Lipoprotein
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high density lipoprotein receptors
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high density lipoprotein binding protein
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Cholesterol