Abstract
We observed a sudden and rapid increase in rare invasive pneumococcal disease serotype 7C, from an annual average of 3 cases during 2000-01 through 2015-16 to 29 cases in 2016-17. The increase was caused almost entirely by clonal expansion of sequence type 177, previously associated with vaccine serotype 19F.
Keywords:
England; ST177; Streptococcus pneumoniae; United Kingdom; Wales; bacteria; capsular switching; invasive pneumococcal disease; pneumococcal conjugate vaccines; replacement disease; sequence type; serotype; serotype 7C.
MeSH terms
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Adolescent
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / pharmacology
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Child
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Drug Resistance, Bacterial
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England / epidemiology
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Female
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Genome, Bacterial
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Phylogeny
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Pneumococcal Infections / epidemiology
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Pneumococcal Infections / microbiology
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Pneumococcal Infections / prevention & control*
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Pneumococcal Infections / transmission*
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Pneumococcal Vaccines / immunology*
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Polymorphism, Single Nucleotide
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Population Surveillance
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Serogroup
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Streptococcus pneumoniae / classification
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / genetics
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Streptococcus pneumoniae / immunology*
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Vaccines, Conjugate / immunology*
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Wales / epidemiology
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Whole Genome Sequencing
Substances
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Anti-Bacterial Agents
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Pneumococcal Vaccines
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Vaccines, Conjugate