Multiple Bowen's diseases and basal cell carcinomas in a patient with acute promyelocytic leukemia treated with arsenic trioxide: A case report and effective treatment with photodynamic therapy

Dermatol Ther. 2018 Nov;31(6):e12718. doi: 10.1111/dth.12718. Epub 2018 Sep 21.

Abstract

It is very rare that multiple Bowen's disease (BD) and basal cell carcinoma (BCC) lesions develop in a single patient. Routine therapy for the multiple lesions is not satisfactory. The present authors report on a patient who had developed multiple BD and BCC lesions for 12 years after arsenic trioxide treatment for his acute promyelocytic leukemia 20 years before. The patient with multiple lesions was successfully treated with photodynamic therapy.

Keywords: Bowen's disease; arsenic trioxide; basal cell carcinomas; photodynamic; therapy.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Arsenic Trioxide / adverse effects*
  • Biopsy
  • Bowen's Disease / chemically induced*
  • Bowen's Disease / drug therapy*
  • Bowen's Disease / pathology
  • Carcinoma, Basal Cell / chemically induced*
  • Carcinoma, Basal Cell / drug therapy*
  • Carcinoma, Basal Cell / pathology
  • Humans
  • Leukemia, Promyelocytic, Acute / drug therapy*
  • Male
  • Middle Aged
  • Photochemotherapy*
  • Skin Neoplasms / chemically induced*
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Arsenic Trioxide