IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex

Scand J Immunol. 2018 Nov;88(5):e12717. doi: 10.1111/sji.12717. Epub 2018 Oct 10.

Abstract

The recently discovered IFN-λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN-λ4 can inhibit HIV infection. Here, we show that IFN-λ4 could suppress HIV infection of macrophages. This IFN-λ4-mediated HIV inhibition was compromised by the antibodies against IFN-λ receptor complex, IFN-λR1/IL-10R2. IFN-λ4 enhanced the phosphorylation of STAT1, and induced antiviral interferon-stimulated genes. These findings indicated that IFN-λ4 can inhibit HIV via JAK/STAT signalling pathway.

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • HIV Infections / immunology*
  • HIV Infections / metabolism
  • HIV Infections / virology
  • Humans
  • In Vitro Techniques
  • Interleukin-10 Receptor beta Subunit / metabolism*
  • Interleukins / metabolism*
  • Interleukins / pharmacology*
  • Macrophages / immunology*
  • Macrophages / metabolism
  • Macrophages / virology*
  • Receptors, Cytokine / metabolism*
  • Receptors, Interferon
  • Recombinant Proteins / pharmacology
  • STAT1 Transcription Factor / metabolism
  • Signal Transduction
  • Virus Replication / immunology

Substances

  • Anti-HIV Agents
  • IFNL4 protein, human
  • IFNLR1 protein, human
  • IL10RB protein, human
  • Interleukin-10 Receptor beta Subunit
  • Interleukins
  • Receptors, Cytokine
  • Receptors, Interferon
  • Recombinant Proteins
  • STAT1 Transcription Factor
  • STAT1 protein, human