Myomaker and Myomerger: It Takes Two to Make One

Nandini N Margam; Roy Duncan

doi:10.1016/j.devcel.2018.09.005

Myomaker and Myomerger: It Takes Two to Make One

Dev Cell. 2018 Sep 24;46(6):676-678. doi: 10.1016/j.devcel.2018.09.005.

Authors

Nandini N Margam¹, Roy Duncan²

Affiliations

¹ Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H4R2, Canada.
² Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H4R2, Canada; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H4R2, Canada; Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada. Electronic address: [email protected].

PMID: 30253167
DOI: 10.1016/j.devcel.2018.09.005

Abstract

Muscle-forming myotubes are formed from the cell-cell fusion of myoblasts. In this issue of Developmental Cell, Leikina et al. (2018) provide compelling evidence that myoblast fusion is dependent on a two-component membrane fusion complex of Myomaker and Myomerger, which function in hemifusion and pore formation activity, respectively.

Publication types

Comment

MeSH terms

Cell Fusion
Membrane Proteins
Muscle Development*
Muscle Proteins*
Myoblasts

Substances

Membrane Proteins
Muscle Proteins