Abstract
The possibility of stimulation of reproduction and antigen production of arboviruses (tick-borne encephalitis, Japanese encephalitis, western equine encephalomyelitis) in cell cultures (SPEV, chick embryo fibroblasts) by using various hormones (insulin, ACTH, hydrocortisone) and optimal temperatures was demonstrated. The stimulating effect depended upon the type of cell culture, virus, method of cell treatment, and manifested by a significant increase of the hemagglutinating and infectious activity of the replicating viruses. Differences in the structure of populations, biophysical and antigenic properties of the viruses associated with the conditions of their reproduction in vitro were observed.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adrenocorticotropic Hormone / pharmacology
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Animals
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Antigens, Viral / analysis
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Arboviruses / drug effects*
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Arboviruses / immunology
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Arboviruses / physiology
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Chick Embryo
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Encephalitis Virus, Japanese / drug effects
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Encephalitis Virus, Japanese / immunology
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Encephalitis Virus, Japanese / physiology
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Encephalitis Virus, Western Equine / drug effects
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Encephalitis Virus, Western Equine / immunology
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Encephalitis Virus, Western Equine / physiology
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Encephalitis Viruses, Tick-Borne / drug effects
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Encephalitis Viruses, Tick-Borne / immunology
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Encephalitis Viruses, Tick-Borne / physiology
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Hormones / pharmacology*
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Hydrocortisone / pharmacology
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Insulin / pharmacology
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Stimulation, Chemical
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Virus Cultivation
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Virus Replication / drug effects*
Substances
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Antigens, Viral
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Hormones
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Insulin
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Adrenocorticotropic Hormone
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Hydrocortisone