Protective effect of resveratrol against pseudorabies virus-induced reproductive failure in a mouse model

Dingding Su; Shusong Wu; Jing Guo; Xiaosong Wu; Qing Yang; Xingyao Xiong

doi:10.1007/s10068-016-0105-8

Protective effect of resveratrol against pseudorabies virus-induced reproductive failure in a mouse model

Food Sci Biotechnol. 2016 Mar 31;25(Suppl 1):103-106. doi: 10.1007/s10068-016-0105-8. eCollection 2016.

Authors

Dingding Su¹, Shusong Wu¹, Jing Guo¹, Xiaosong Wu¹, Qing Yang², Xingyao Xiong³

Affiliations

¹ 1College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, 410128 China.
² 2College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, 410128 China.
³ Hunan Province Key Laboratory of Crop Germplasm Innovation and Utilization, Changsha, Hunan, 410128 China.

Abstract

Resveratrol (RES), a natural polyphenol that is abundant in grapes, exerts anti-inflammatory, anti-oxidative, and antiviral bioactive effects. Protective effects of RES against pseudorabies virus (PrV)- induced reproductive failure were investigated in a mice model. Injection of PrV partially induced stillbirth and abortion, and caused poor growth of progeny. Treatment with RES attenuated the reproductive failure induced by the virus with recovery of the serum progesterone level. RES improved the growth performance of newborn mice. RES can attenuate the reproductive failure induced by PrV in mice.

Keywords: antivirus; pseudorabies; reproductive failure; resveratrol.