Nanozyme as Artificial Receptor with Multiple Readouts for Pattern Recognition

Anal Chem. 2018 Oct 16;90(20):11775-11779. doi: 10.1021/acs.analchem.8b03807. Epub 2018 Oct 1.

Abstract

Nanozymes have been widely used for the construction of colorimetric sensors. However, the simultaneous discrimination of multiple targets using nanozymes is still a challenge. In this work, we construct a multiple-readout system for pattern recognition of proteins using nanozyme. Graphitic carbon nitride (g-C3N4) nanosheets, which possess peroxidase-like activity, are chosen as the single sensing receptor. The catalytic activity of g-C3N4 can be changed to different degrees owing to the different interactions between g-C3N4 and proteins. By choosing different combinations of absorbance intensities at various time points, multichannel information can be extracted from a single material for pattern recognition. The platform avoids the synthesis of multiplex sensing receptors and the requirement of sophisticated instruments, leading to lower cost and time consumption. The study provides a new method for the construction of feasible, convenient, and flexibly nanozyme-based sensing arrays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Colorimetry*
  • Graphite / chemistry*
  • Nanostructures / chemistry*
  • Nitrogen Compounds / chemistry*
  • Pattern Recognition, Automated*
  • Principal Component Analysis
  • Proteins / analysis*
  • Receptors, Artificial / chemistry*

Substances

  • Nitrogen Compounds
  • Proteins
  • Receptors, Artificial
  • graphitic carbon nitride
  • Graphite