Intravenous Iron Therapy in Heart Failure

Natasha L Altman; Amit Patel

doi:10.1016/j.hfc.2018.06.003

Intravenous Iron Therapy in Heart Failure

Heart Fail Clin. 2018 Oct;14(4):537-543. doi: 10.1016/j.hfc.2018.06.003. Epub 2018 Aug 18.

Authors

Natasha L Altman¹, Amit Patel²

Affiliations

¹ Section of Advanced Heart Failure and Transplant, Division of Cardiology, Department of Medicine, University of Colorado Denver, 12631 East 17th Avenue, Aurora, CO 80045, USA. Electronic address: [email protected].
² Advanced Heart Failure and Cardiac Transplantation, St. Vincent Medical Group, 8333 Naab Road, Suite 400, Indianapolis, IN 46260, USA.

PMID: 30266362
DOI: 10.1016/j.hfc.2018.06.003

Abstract

Iron deficiency anemia is both a comorbid condition and an indicator of poor prognosis in heart failure. The mechanisms by which this occurs are multiple and complex. Recent robust randomized clinical trials have shown significant improvements in quality of life and rates of hospitalization with intravenous repletion of iron. In this article, we review the mechanisms by which iron deficiency impacts heart failure and the evidence behind repletion. There remains a good deal to learn about long-term effects of intravenous iron repletion, and clinical trials are ongoing in this regard.

Keywords: Anemia; Ferrous carboxymaltose; Heart failure; Intravenous (IV) iron; Iron deficiency; Peak oxygen consumption.

Publication types

Review

MeSH terms

Administration, Intravenous
Anemia, Iron-Deficiency* / blood
Anemia, Iron-Deficiency* / drug therapy
Anemia, Iron-Deficiency* / etiology
Heart Failure* / blood
Heart Failure* / complications
Heart Failure* / drug therapy
Humans
Iron / administration & dosage*

Substances

Iron