The isolation, absolute configuration and activities of 18(4 → 3)-abeo-abietane lactones from Tripterygium wilfordii

Bioorg Chem. 2019 Feb:82:68-73. doi: 10.1016/j.bioorg.2018.09.031. Epub 2018 Sep 24.

Abstract

Phytochemical studies on the leaves of Tripterygium wilfordii led to the isolation of seven new 18(4 → 3)-abeo-abietane lactones, triptergulides E - K (1 - 7). The structure of the new compounds was elucidated on the basis of their spectroscopic analysis, and the absolute configurations of compounds were confirmed by ECD, calculated ECD, and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Some compounds showed moderate inhibitory activities against NO, IL-6, and TNF-α production in LPS RAW 264.7 macrophage in vitro.

Keywords: Anti-inflammation; Triptergulide; Tripterygium wilfordii; abeo-abietane lactone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemistry*
  • Abietanes / isolation & purification
  • Animals
  • Interleukin-6 / antagonists & inhibitors
  • Lactones / chemistry*
  • Lactones / isolation & purification
  • Mice
  • Nitric Oxide / antagonists & inhibitors
  • Plant Leaves / chemistry
  • RAW 264.7 Cells
  • Stereoisomerism
  • Tripterygium / chemistry*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

  • Abietanes
  • Interleukin-6
  • Lactones
  • Tumor Necrosis Factor-alpha
  • interleukin-6, mouse
  • Nitric Oxide