Cobalt-Catalyzed Selective Hydrogenation of Nitriles to Secondary Imines

Org Lett. 2018 Oct 19;20(20):6430-6435. doi: 10.1021/acs.orglett.8b02744. Epub 2018 Oct 1.

Abstract

The first example of cobalt-catalyzed selective hydrogenation of nitriles to secondary imines is reported. The results demonstrate the significantly different selectivity compared with the previously reported cobalt catalytic system during the nitrile hydrogenation. A variety of aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines.

Publication types

  • Research Support, Non-U.S. Gov't