Abstract
We describe the case of a patient with severe fever with thrombocytopenia syndrome (SFTS) complicated by SFTS-associated encephalopathy who was successfully treated with 4-day plasma exchange followed by two-time convalescent plasma therapy. During plasma exchange, the plasma cytokines interferon-α and inducible protein-10 gradually decreased without change of plasma viral load. However, plasma viral load gradually decreased after convalescent plasma therapy. This case provides important insights for understanding the mechanisms of experimental therapy in severely affected SFTS patients.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antibodies, Viral / biosynthesis
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Antibodies, Viral / blood*
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Antiviral Agents / therapeutic use
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Brain Diseases / immunology
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Brain Diseases / pathology
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Brain Diseases / therapy*
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Brain Diseases / virology
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Bunyaviridae Infections / immunology
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Bunyaviridae Infections / pathology
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Bunyaviridae Infections / therapy*
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Bunyaviridae Infections / virology
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Chemokine CXCL10 / blood
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Chemokine CXCL10 / immunology
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Convalescence
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Critical Illness
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Humans
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Interferon-alpha / blood
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Interferon-alpha / immunology
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Male
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Phlebovirus / immunology
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Phlebovirus / pathogenicity*
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Plasma Exchange / methods*
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Republic of Korea
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Ribavirin / therapeutic use
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Therapies, Investigational / methods*
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Tissue Donors
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Treatment Outcome
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Viral Load
Substances
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Antibodies, Viral
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Antiviral Agents
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CXCL10 protein, human
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Chemokine CXCL10
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Interferon-alpha
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Ribavirin